The Effect of Deep Neuromuscular Blockade on Requirement of Intravenous Anesthetic Agent

• Status: Completed
• Trial end date: 2020-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Recently, deep neuromuscular blockade during general anesthesia has been studied by many authors regarding various effects upon patients' outcomes and surgical conditions. We believe deep neuromuscular blockade can be especially beneficial in laparoscopic surgery, because it can expand surgical space and prevent patients' minute movements that can disturb precise operations. In clinical situations, anesthetists tend to compensate the insufficiency of neuromuscular blockade by increasing the dose of other anesthetic agents, which can prolong patients' recovery time and impair the surgical condition. In this study, we plan to divide the patients into 2 groups according to the depth of neuromuscular blockade, and compare the dose of anesthetic agent used to maintain surgical condition.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Bundang Hospital
• Treatments: Anesthetics; Anesthetics, Intravenous; Rocuronium

Criteria

Inclusion Criteria:

• Patients undergoing elective laparoscopic colorectal resection due to benign or malignant neoplasm of colon or rectum

• ASA class I or II

Exclusion Criteria:

• Patients receiving medications known to have drug-drug interaction with neuromuscular blocking agents

• Patients who have significantly impaired cardiac, pulmonary, hepatic, renal function

• Patients who are pregnant

• Patients who are known to have hypersensitivity to the anesthetic/analgesic/neuromuscular blocking agents which are going to be used in the study

• BMI < 18.5 or > 35.0 kg/m2

• Patients with previous history of open abdominal surgery

• Patients with previous history of malignant hyperthermia