The Effect of D-cycloserine on Emotional Processing

• Status: Completed
• Trial end date: 2018-12-05
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the effects of N-methyl-D-aspartate (NMDA) partial agonist DCS on emotional processing, memory and stress tasks

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Treatments: Cycloserine

Criteria

Inclusion Criteria:

• Male or female

• Willing and able to give informed consent for participation in the study

• Body mass index (BMI) within the range of 19-30kg/m2

• Sufficiently fluent English to understand and complete the task

Exclusion Criteria:

• Currently take any psychoactive medication.

• Have taken any CNS-active medication during the last 6 weeks.

• Currently take any medication with cycloserine, ethionamide or isoniazid

• Have suffered from any past or current psychiatric disorder (e.g. depression, anxiety)

• Have lifetime history of epilepsy or other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.

• Have history of heart disease, significant hypertension

• Have history of Megaloblastic Anaemia, Sideroblastic Anaemia

• Have history of kidney disease with reduction in kidney function

• Have severe renal impairment

• Have suffered from lactose intolerance

• Are currently pregnant, breastfeeding or trying to get pregnant

• Have a current or past history of drug or alcohol dependency

• Have participated in a psychological or medical study involving the use of medication within the last 3 months

• Have previously participated in a study using the same, or similar, emotional processing tasks

• Smoke more than 5 cigarettes per day

• Have dyslexia (given the nature of the computer tasks)