The Effect of Curcumin on the Development of Prednisolone-induced Hepatic Insulin Resistance
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to investigate whether ingestion of curcumin will prevent hepatic
insulin resistance (assessed by homeostatic model assessment of insulin resistance (HOMA-IR))
induced by short-term oral glucocorticoid (prednisolone) administration in overweight and
obese participants. As a secondary endpoint it will be investigated if prednisolone
administration induce or worsen the degree of NAFLD in overweight or obese participants using
magnetic resonance (MR) spectroscopy (MRS), and if curcumin can ameliorate this effect. Also,
the possible anti-inflammatory effect of curcumin will be elucidated as a range of
inflammatory markers before and after intervention will be measured. Thus, prednisolone
treatment is used as a model of development of pre-diabetes.