The Effect of Combining Aprepitant With Ondansetron in High-risk Patients for Postoperative Nausea and Vomiting
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
PONV (Postoperative nausea and vomiting) is one of most common complications after general
anesthesia. Female sex, history of PONV, motion sickness, nonsmoker status, use of volatile
agents, duration of anesthesia, opioid administration and laparoscopic surgery are known as
risk factors for developing PONV. In consequence, patients undergoing laparoscopic
gynecologic surgery are at high risk for developing PONV. Most of these patients use fentanyl
based IV-PCA. And it also causes PONV.
So, we should prevent PONV in these patients by using multimodal or combination therapy.
Aprepitant is a NK1 receptor antagonist.And it is used to prevent chemotherapy induced nausea
and vomiting. Many studies using aprepitant to prevent PONV are in progress.
In this study, we investigate the effect of combining aprepitant with ondansetron in
high-risk patients for PONV.