The Effect of ColcHicine on the Incidence of Knee or Hip Replacements
Status:
RECRUITING
Trial end date:
2029-03-31
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to evaluate the effect of treatment with colchicine 0.5mg once daily as compared to placebo in patients with knee or hip osteoarthritis on the incidence of first occurrence of knee or hip replacement. The main question it aims to answer is:
Does colchicine lower the number of knee or hip replacements in participants with osteoarthritis?
Researchers will compare colchicine to a placebo (a look-alike substance that contains no drug) to see if colchicine works to treat osteoarthritis.
Participants will:
* take colchicine every day for 3 tot 4.5 years
* visit the clinic every year for check-up and tests such as blood samples and x-rays
* fill in questionnaires every 3 months
Phase:
PHASE3
Details
Lead Sponsor:
Sint Maartenskliniek
Collaborators:
Dutch Arthritis Foundation Reuma Nederland RSMK Tiofarma ZonMw: The Netherlands Organisation for Health Research and Development