The Effect of Chemoradiotherapy on Gastric Perfusion in Patients With Gastric Cancer.
Status:
Recruiting
Trial end date:
2024-04-01
Target enrollment:
Participant gender:
Summary
A study from our group (Osterkamp et al. in preparation) used ICG to evaluate intraoperative
changes in gastric perfusion when reducing the circulating blood volume by blood withdrawal
in pigs. We saw a significant reduction in gastric perfusion with decreased blood volume, and
this reduction of gastric perfusion was detectable with ICG. As data from a previous trial
(PRESET phase 2 Protocol nr: H-15014904) has shown that chemotherapy decreases the
circulating red blood cell volume in patients with gastroesophageal cancer, we wish to
evaluate if standard care neoadjuvant chemotherapy also influences gastric perfusion. Gastric
perfusion will be assessed during a screening laparoscopy (before chemotherapy) and then
compared with a second assessment during gastric resection (after chemotherapy). The gastric
perfusion will be measured using fluorescence-guided surgery with Indocyanine Green.