The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding

• Status: Unknown status
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the efficacy and safety of Carvedilol and Propranolol in patients with cirrhosis-related esophagogastric varices after multiple endoscopic treatments for secondary prophylaxis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Zhongshan Hospital
• Treatments: Carvedilol; Propranolol

Criteria

Inclusion Criteria:

• age between 18-70 years old;

• cirrhotic patients referred to Zhongshan Hospital with esophagogastric varices confirmed by endoscopy;

• history of variceal bleeding; at least 3 times of endoscopic treatment;

• with 1) mild esophageal varices;2) gastric varices with a diameter less than 5mm; or 3) variceal eradication at the time of recruiting.

Exclusion Criteria:

Patients are excluded when they have

• episodes of variceal bleeding after the last endoscopic treatment;

• diagnosis of hepatic cellular carcinoma;

• severe systemic diseases;

• refractory ascites;

• contraindication to Carvedilol or Propranolol, such as: asthma, chronic obstructive pulmonary disease, allergic rhinitis, New York Heart Association IV chronic heart failure, atrioventricular blockade, severe bradycardia(HR<50bpm), sick sinus syndrome, cardiogenic shock, severe hypotension(ABPsys<85mmHg);

• previous and continued use of β-blockers;

• Child -Pugh Class C.