The Effect of Broccoli Sprout Extract and Probiotics for Eradication of Helicobacter Pylori
Status:
Unknown status
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
In Korea, the first-line therapy to treat Helicobacter pylori (Hp) consists of a proton pump
inhibitor (PPI) and two antibiotics for one week. But, eradication has become less successful
due to low compliance and high resistance to the antibiotics. Therefore, it is necessary to
develop new treatment strategies that increase the eradication rate and reduce adverse
effects. In vitro study, we previously reported that a broccoli sprout extract containing
sulforaphane may prevent lipid peroxidation in the gastric mucosa and play a cytoprotective
role in Hp-induced gastritis. Also, several studies suggested that probiotics could be
effective for improving Hp eradication rate or reducing adverse events. But, their effect for
eradication of Hp is not yet conclusive. The aims of this prospective study is to investigate
the efficacy of a broccoli sprout extract containing sulforaphane and probiotics for
eradication of Hp, compared with standard triple therapy.