The Effect of Beta-Blockers and Aspirin on Hemostasis and Endothelial Function After Acute Mental Stress
Status:
Unknown status
Trial end date:
2004-08-01
Target enrollment:
Participant gender:
Summary
This randomized double-blinded controlled trial uses a factorial design to investigate
whether application of beta-blockers (inderal 80 mg) or aspirin (100 mg) or a combination
thereof has an effect on the activation of the hemostatic system, the platelets and the
endothelium in response to acute mental stress. Specifically we test the hypothesis that
inderal attenuates the activation of the hemostatic system as compared to placebo. The second
hypothesis is that aspirin attenuates the activation of platelets as compared to placebo.
Subjects will be randomly allocated to either of the four following study arms: placebo -
inderal - aspirin - inderal plus aspirin. Subjects will receive the study medication for five
days prior to the mental stress. The acute mental stress consists of a public speaking
session of 10 min duration immediately followed by a mental arithmetic test of 5 min
duration. Blood will be collected prior to the stress, immediately thereafter, at 45 min at
at 1 hour and 45 min.