The Effect of BIS Monitorization to Intraoperative Anesthetic Consumption During Coronary Artery Surgery

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: All

Summary

213 patients undergoing elective on-pump coronary artery bypass grafting (CABG) were enrolled into this prospective-clinical trial.After hundred and sixty three patients were excluded due to various reasons, 50 patients were randomized to BIS (bispectral index) and MAC (minimum alveolar concentration) groups. In BIS group (Group B, n=25), desflurane was titrated within 40 to 60 BIS values and in MAC group (Group M, n=25) within 0.7 to 1.3 MAC. Primary end point of the study was to investigate the difference of desflurane consumption between groups.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Baskent University Ankara Hospital; Baskent Univesity Ankara Hospital
• Treatments: Anesthetics; Desflurane; Isoflurane

Criteria

Inclusion Criteria:

• Undergoing elective on-pump CABG surgery

• Having an American Society of Anesthesiologists' (ASA) physical status of 3 to 4

Exclusion Criteria:

• A contraindication to the administration of the study drugs

• History of psychiatric and/or neurological disorder

• A left ventricular ejection fraction (EF) < 30%

• A body mass index (BMI) > 30 kg/ m2

• Urgent surgery

• Myocard infarction within 48 hours

• Preoperative need for inotropic/vasodilator agents

• History of heart surgery

• Preoperative or intraoperative need for intraaortic balloon pump

• Left ventricular aneurysms

• Severe pulmonary, renal or hepatic dysfunction

• Presence of excessive alcohol intake or drug abuse