Overview
The Effect of Atorvastatin on Renal Function in Healthy Subjects During Normal and High Sodium Intake
Status:
Completed
Completed
Trial end date:
2007-10-01
2007-10-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and high sodium intake.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Regional Hospital HolstebroTreatments:
Atorvastatin
Atorvastatin Calcium
Criteria
Inclusion Criteria:1. Age 20-50 yr
2. BMI<30
3. Females had to use oral contraceptive treatment or IUD.
Exclusion Criteria:
1. Clinical signs or history of disease of the heart, lungs, kidneys, liver, brain or
endocrine organs
2. Abnormal laboratory blood tests (hemoglobin, sodium, potassium, albumin, creatinine,
blood glucose, bilirubin, alanin amino transferase, alkalic phosphatase)
3. Albuminuria or glucosuria
4. cancer
5. arterial hypertension
6. alcohol abuse
7. medical treatment, except contraceptives
8. pregnancy or breast feeding
9. blood donation one month before the study.