The Effect of Atorvastatin on Androgens, Glucose Metabolism and Inflammation in Polycystic Ovary Syndrome (PCOS) Women

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

This is a placebo controlled trial investigating the effect of 6 months atorvastatin 20mg/day therapy on androgens, glucose metabolism and inflammatory markers in women with PCOS.

We assume that during 6 months atorvastatin therapy a significant improvement in hyperandrogenism, glucose metabolism and inflammatory markers is observed.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oulu
• Collaborator: Pfizer
• Treatments: Androgens; Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• diagnosed for PCOS (Rotterdam criteria)

• aged 30-50 years

• safe non-hormonal contraception

Exclusion Criteria:

• use of cholesterol lowering agents

• use of antidepressants

• use of cortisone medication (p.o.)

• use of hormonal contraception

• nursing

• pregnancy

• DM-T2

• liver disease

• menopause

• kidney or liver failure