Overview

The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury

Status:
Unknown status
Trial end date:
2019-08-01
Target enrollment:
0
Participant gender:
All
Summary
This is a double-blind, placebo-controled, randomized trial to investigate if aspirin pre-treatment has anti-inflammatory effects in a model of acute lung injury induced by inhaled endotoxin (LPS) in healthy human volunteers.
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Belfast Health and Social Care Trust
Collaborators:
Northern Ireland Clinical Trials Unit
Queen's University, Belfast
The Intensive Care Society United Kingdom
Treatments:
Aspirin
Criteria
Inclusion Criteria:

- Healthy subjects

Exclusion Criteria:

- Age < 18 years

- Pregnancy or breast feeding or woman of childbearing potential not using

- adequate contraception.

- Participation in a clinical trial of an investigational medicinal product within 30
days

- Consent declined Aspirin or non steroidal anti-inflammatory (NSAID) use in the past 4
weeks

- History of asthma

- Known aspirin or NSAID hypersensitivity

- History of peptic ulcer disease

- Platelet count < 150 x 106/ml

- Aspirin resistance