The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of aspirin desensitization on symptoms and immunologic profile of patients with aspirin-exacerbated respiratory diseases (AERD).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tehran University of Medical Sciences
• Collaborator: Rassoul Akram Hospital
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• Patients with clinical diagnose of aspirin-exacerbated respiratory disease

• History of physician diagnosed asthma.

• History of physiacian diagnosed chronic rhinosinositis with nasal polyps.

• Positive reaction to aspirin challenge test.

• Stable asthma (post-bronchodilator FEV1 of 70% or better, no increase in baseline dose of oral glucocorticoids for at least 3 months, and no history of hospitalization or emergency room visits for asthma for at least the prior 6 months).

Exclusion Criteria:

• Being smoker

• pregnancy

• Current breastfeeding

• History of bleeding diathesis

• History of transient ischemic attack or stroke, or diabetes.

• History of abnormal hepatic function

• Uncontrolled hypertension or use of beta blocker medication.

• History of gastrointestinal ulcers or gastrointestinal bleeding.