Overview

The Effect of Anticholinergics on Cognitive Function in the Elderly

Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
0
Participant gender:
Female
Summary
Anticholinergic medication is used to treat overactive bladder (OAB). A known side effect of this medication is cognitive dysfunction. OAB is more prevalent in the elderly population - a group that also has a higher baseline risk of cognitive dysfunction. Our objective is to evaluate the effect of an anticholinergic medication on cognitive function in elderly women.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborator:
American Urogynecologic Society
Treatments:
Cholinergic Antagonists
Trospium chloride
Criteria
Inclusion Criteria:

- Female 50 or older

- Diagnosis of OAB (ICS definition)

- English literacy

- Ability to swallow oral medication

- Cognitive ability to give consent

Exclusion Criteria:

- Dementia/Depression/Delirium

- Current anticholinergic use (requires 2 week washout period)

- Current cholinesterase

- Urinary or gastric retention

- Severe decreased gastrointestinal motility

- Uncontrolled narrow-angle glaucoma

- Myasthenia gravis

- Diagnosis fo renal impairment (creatinine clearance <30 mL/min)