The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major
Status:
Completed
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
The accumulation of unpaired α-globin chains in β-thalassemia major patients may clinically
create ineffective erythropoiesis, hemolysis, and chronic anemia. Multiple blood transfusions
and iron overload cause cellular oxidative damage. However, α-tocopherol, an antioxidant, has
been known as a potent scavenger of lipid radicals in the red cell membrane of β-thalassemia
major patient. By this randomized controlled trial, the investigators would like to evaluate
the effects of α-tocopherol in hemolysis and oxidative stress on the red cell membrane of
β-thalassemia major.
Phase:
N/A
Details
Lead Sponsor:
Indonesia University
Treatments:
alpha-Tocopherol Tocopherols Tocotrienols Vitamin E