The Effect of Allergen Inhalation on Sputum Myeloid and Plasmacytoid Dendritic Cells in Mild Atopic Asthmatics
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Summary:
A picture is emerging of dendritic cells migrating through the blood to the airways following
allergen inhalation in atopic asthmatics. Although the Koh and McCarthy articles present
novel findings, both do not provide a comprehensive view of sputum DCs following allergen
challenge. Therefore, the proposed study will examine the kinetics of mDCs and pDCs in the
induced sputum of atopic asthmatics following inhalation of allergen.
Hypothesis:
Following allergen challenge, sputum myeloid and plasmacytoid DCs will migrate into the
airway lumen in atopic asthmatics during the timeframe of the late asthmatic response.
Objective:
The objective of this study is to examine the kinetics of dendritic cells in induced sputum
following allergen challenge in atopic asthmatic subjects.