The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.

• Status: Completed
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

We investigated the effect of the administration of small doses of thyroxine to healthy humans and patients with type 2 diabetes on postprandial forearm muscle glucose uptake, insulin sensitivity indices, lipid metabolism, in vitro glucose uptake and GLUT4 recruitment in the plasma membrane of monocytes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Attikon Hospital

Criteria

Inclusion Criteria:

• Healthy or treatment naive type 2 diabetes euthyroid subjects, with a micronodular texture of the thyroid gland.

• Recreationally active

• With stable body weight and diet during the last two months.

Exclusion Criteria:

• Any systemic disease(besides glucose abnormalities)

• Any medication therapy

• Diabetic complications