Overview

The Effect of Acute Lysine Administration on α-aminoadipic Acid (Sub-study)

Status:
Completed
Trial end date:
2017-05-18
Target enrollment:
0
Participant gender:
All
Summary
This sub-study aims to assess the effect and breakdown of lysine administration, specifically examining whether it leads to increased plasma 2-AAA in healthy humans.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Vanderbilt University Medical Center
Criteria
Inclusion Criteria:

- BMI 18 to <25 kg/m2

- Men and women ages 18-45 years

Exclusion Criteria:

- Current use of prescription medications (apart from hormonal birth control)

- Current use of amino acid supplements (including branched-chain amino acids) or
supplemental protein (habitual consumption of protein powder, bars, shakes), and
unwilling to temporarily discontinue use (1 week prior to study visit)

- Individuals who currently use tobacco products or have done so in the previous 30 days

- Prior or current cardiovascular disease, renal disease, or liver disease

- Diabetes mellitus (taking insulin, other anti-diabetic agents, or diet-controlled)

- Atrial fibrillation

- Bleeding disorder or anemia

- Positive pregnancy test

- Women who are breastfeeding

- Participation in another clinical trial within the previous 6 weeks prior to the study
visit

- Inability to provide written informed consent

- Inability to fast for 8 hours