The Effect and Safety of Different Intensity Anticoagulation Therapy in Elderly Patients With Non-valvular Atrial Fibrillation

• Status: Completed
• Trial end date: 2012-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Current guidelines recommend standard warfarin anticoagulation international normalized ratio (INR) goal of 2.0-3.0 in adults with non valvular atrial fibrillation (NVAF). The investigators hypothesized that low-intensity warfarin (INR 1.5-2.0) has the same effectiveness and better security in elderly patients (>75) with NVAF.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nanjing Medical University
• Treatments: Aspirin; Warfarin

Criteria

Inclusion Criteria:

1. Clinical diagnosis of atrial fibrillation

2. Echocardiography confirmed a non-valvular heart disease

3. Age≥75 years

Exclusion Criteria:

1. Unable to cooperate with doctors

2. Life expectancy of less than 1 year

3. Rheumatic heart disease or dilated cardiomyopathy

4. History of artificial valve replacement surgery

5. Infectious endocarditis

6. Stroke or transient ischemic attack(TIA) within the last 6 months

7. Previous history of intracranial hemorrhage, gastrointestinal, respiratory or urogenital bleeding

8. Previous intolerance/allergy to warfarin or aspirin

9. Blood pressure greater than 180/110 mmHg

10. Chronic liver dysfunction, alanine aminotransferase above the normal reference value of the upper limit 3 times

11. Chronic renal failure, serum creatinine clearance rate (Ccr) less than 30 ml / min

12. Patient was receiving antiplatelet or anticoagulant therapy due to other reasons