Overview
The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular Teeth
Status:
Unknown status
Unknown status
Trial end date:
1969-12-31
1969-12-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2. There have been many studies demonstrating the bone-promoting effect of local application various animal models including after application into socket of teeth in a rat. the purpose of the study is to investigate the effect of slow release topical simvastatin in socket of mandibular teeth on bone remodeling in the socketPhase:
N/AAccepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Hadassah Medical OrganizationTreatments:
Simvastatin
Criteria
Inclusion Criteria:- need extraction of single root tooth
- intend to have prosthetic implant in place of extraction
Exclusion Criteria:
- treated with simvastatin P.O for hypercholesterolemia