The Effect Of Dose Titration And Dose Tapering On The Tolerability Of DVS SR In Women With Vasomotor Symptoms
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Desvenlafaxine succinate (DVS SR) is a serotonin and norepinephrine reuptake inhibitor
(SNRI). It is a nonhormonal option for the treatment of Vasomotor Symptoms (VMS) associated
with menopause. Nausea is the most common adverse event that is observed in clinical studies
and is the main reason for discontinuation during the first week of therapy. Other adverse
events (headache, nausea, and dizziness) associated with DVS SR have been noted to occur when
subjects abruptly discontinue the medication. The purpose of this study is to evaluate
several titration and tapering regimens of DVS SR to ensure a better tolerability profile at
the start and completion of treatment. In addition, this study will provide a long
posttreatment follow-up to assess any symptoms after treatment is discontinued.