The Effect Effect of Empagliflozin on Oxidative Stress in Patients With Type 2 Diabetes
Status:
Completed
Trial end date:
2020-01-22
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of empagliflozin on oxidative stress
in patients with type 2 diabetes. The association is examined by comparing the difference in
oxidative modifications before and after 14 days treatment with 25 mg empagliflozin compared
to placebo treatment. The study is randomised, double-blinded, and placebo controlled. Each
treatment group consists of 17 males with type 2 diabetes. Oxidative modifications are
measured by urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and
8-oxo-7,8-dihydroguanosine. A student t-test will be performed to compare the drug treatment
with placebo. The results will be published in a peer-review journal.
Phase:
Phase 2
Details
Lead Sponsor:
Henrik Enghusen Poulsen
Collaborators:
University Hospital, Gentofte, Copenhagen University of Copenhagen