The Effect Dialysis on the Pharmacokinetics of Fexofenadine
Status:
Unknown status
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
The Investigators recently completed and published a study that demonstrated that
fexofenadine pharmacokinetics are significantly altered in dialysis patients (Thomson et al.
(2015) American Journal of Kidney Diseases 65(4):574-582). In this study, patients were
studied directly before routine dialysis treatment. Other published literature suggests the
timing of the dose of some drugs (before or after dialysis) may have a profound impact on the
drug pharmacokinetics (Nolin et al (2006) 17(9):2363-7). The hypothesis is that compounds
that accumulate in the blood of patients with kidney failure impact the pharmacokinetics such
that dosing before or after dialysis produces significantly different blood levels of the
drug.