The ED50 of DEX for Providing Sedation in Different Female Age Group
Status:
Unknown status
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Dexmedetomidine(DEX) could provide dose-dependent sedation , analgesia , anti-anxiety and
inhibition of sympathetic nerves and other effects. Because of its minimal impact on the
respiratory , currently it was more and more widely used to sedate patients undergoing
regional anesthesia.Many anesthetic pharmacokinetics and pharmacodynamics are often affected
by age, and current studies with regard to the effects of age on dexmedetomidine
pharmacodynamic are rare. This study was designed to explore the right DEX dose of different
female Age of patients to produce suitable sedation.Dexmedetomidine be used in patients with
combined spinal and epidural anesthesia for sedation,which is monitored by the
Narcotrend,during the operation.The relation between Narcotrend index (NTI) and the depth of
sedation for patients is also investigated.
Phase:
Phase 4
Details
Lead Sponsor:
Guangzhou General Hospital of Guangzhou Military Command