The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure

• Status: Completed
• Trial end date: 2018-02-21
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study will be to determine the effects of pilocarpine as an adjunct medication to latanoprost monotherapy at multiple intervals throughout a 24-hour period and compare these effects to latanoprost alone.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Treatments: Latanoprost; Pilocarpine

Criteria

Inclusion Criteria:

• Current confirmed diagnosis of:

• open angle glaucoma, or

• ocular hypertension including pigment dispersion glaucoma, and

• pseudoexfoliation glaucoma.

• Current use of topical latanoprost once a day in both eyes for at least 6 weeks

• any race/ethnicity

Exclusion Criteria:

• Females who are currently pregnant or planning to become pregnant during the study period

• Diagnosis of any other form of glaucoma other than open-angle

• Intraocular pressure readings of <14mmHg in either eye when measured during routine office visit in the past 12 months.

• Schaffer angle grade < 2 in either eye by gonioscopy

• Intraocular surgery within 6 months or laser within 3 months

• History of retinal tear or detachment in either eye

• Active iritis in either eye as determined by most recent eye examination

• Patients who smoke or have irregular daily sleep patterns

• Patients who have started or changed glucocorticoids therapy in the last 3 months

• Patients who are currently using medical or recreational marijuana

• Any use of a non-FDA approved medication for glaucoma in the last 3 months