The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children

• Status: Completed
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The study will ascertain the ability of preschool lung function tests to distinguish healthy children from those with wheeze, and to differentiate phenotypes of wheezy children (high and low risk for asthma as defined by API) in order to predict response to therapy, and to explore the correlation between preschool lung function test results and symptoms, in order to develop objective methods for monitoring asthma.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Hospital for Sick Children
• Collaborator: Dalhousie University
• Treatments: Albuterol; Bronchodilator Agents

Criteria

Inclusion Criteria (Wheezing Subjects):

• 3 to 5 years of age (36 to 71 months)

• Diagnosis of Asthma made by a physician in the emergency department

• History of at least two other wheezing episode within the previous 12 months

• Received salbutamol within 4hrs before emergency department visit, during current emergency department visit, or was prescribed salbutamol at discharge from emergency department.

Inclusion Criteria (Healthy Controls):

• 3 to 5 years of age (36 to 71 months)

• Free of a respiratory infection for a minimum of 4 weeks prior to the testing visit

Exclusion Criteria (both subjects and controls):

• History or coexistence of renal, chronic pulmonary, cardiac, neurological or systemic disease

• Born pre-term (< 35 weeks GA)

• Insufficient command of the English language