The Correlation Between Vitamin A / E Levels and Preeclampsia
Status:
Recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
Vitamin A (VA) and vitamin E (VE) are fat-soluble vitamins and indispensable substances in
life activities.
VA plays an important role in visual function, normal formation and development of epithelial
cells, development and growth of bones, immune function and reproductive health. VA is of
great significancCe for the growth and development of embryonic cells, especially for the
development of fetal vertebrae, spinal cord, limbs, heart, eyes and ears. The lack of
maternal VA will lead to the stunted development of fetal organs and tissues, and even fetal
developmental malformation. In addition, VA has a protective effect on neonatal lung
maturation.VA deficiency can cause the decrease in the activity of enzymes needed to catalyze
the formation of progesterone precursors in pregnant women, reduce the production of steroids
in adrenal glands, gonads and placenta, and seriously affect the functions of multiple organs
such as heart, liver and skeletal muscle in pregnant women.
VE, also known as tocopherol, has non-enzymatic antioxidant function, and maintains the
balance of REDOX reaction in vivo by efficiently removing free radicals generated by lipid
peroxidation.VE can increase the synthesis of nitric oxide (NO) in endothelial cells and
improve vascular endothelial function. Long-term administration of VE can improve the
impaired endothelium-dependent vasodilatory function in patients.VE can promote sex hormone
secretion, improve fertility and prevent abortion. Pregnancy women the body's metabolism,
increases produce free radicals, lipid peroxidation, low levels of VE will result in the
accumulation of excess free radicals, cause the placenta aging, vascular endothelial damage,
increase the risk of the occurrence of PHI and adverse outcome rate, as well as the membranes
of cell membrane damage, increase the risk of premature rupture of membranes.
Gestational hypertension is a group of diseases with both pregnancy and elevated blood
pressure, and is the main cause of increased maternal and perinatal mortality, mainly
including gestational hypertension, preeclampsia PE, and eclampsia, as well as chronic
hypertension with preeclampsia and chronic hypertension with pregnancy. The cause of PE is
unknown, but studies have found that it may be related to insufficient recast of spiral
uterine arterioles, excessive activation of inflammatory immune system, damage of vascular
endothelial cells, genetic factors, nutritional deficiency and insulin resistance. Recent
studies have found that free radical oxidative damage may also be one of the main reasons for
the occurrence and development of PE. PE occurs, the placenta bed vasospasm, ischemia,
angiogenesis blocking and endothelial atherosclerotic changes, local immune cell activity,
make produce free radicals increases, interfere with the vascular endothelial cell function,
reduce vascular relaxation material synthesis, and shrink blood vessels increase material
synthesis, promote vascular spasm, platelet condensed state is changed, thus appeared a
series of PE.
Previous studies have shown that oxygen free radicals and lipid peroxides are increased in
PHI patients, while the levels of VA and VE are closely related to the antioxidant capacity
of the body, and their lack can lead to the imbalance of the homeostasis of redox reaction in
multi-tissue cells in the body. Since both VA and VE belong to fat-soluble vitamins and are
widely distributed in daily food, whether their effects on the occurrence and development of
PE are independent or combined will be a question for us to explore. Therefore, this study
intends to evaluate the correlation between VA, VE and VA+VE and PE occurrence through
multi-center clinical studies, and explore and summarize the feasibility of VA and VE in PE
adjuvant treatment.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Treatments:
alpha-Tocopherol Retinol palmitate Tocopherols Tocotrienols Vitamin A Vitamin E Vitamins