Overview

The Contribution of Incretin Hormones to Post-prandial Glucose Metabolism After Roux-en-Y Gastric Bypass

Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
0
Participant gender:
All
Summary
The study is being undertaken to understand how the Roux-en-Y Gastric Bypass procedure can affect insulin secretion after meals. The hypothesis of this study is the Disposition Index is decreased in subjects who had previously undergone Roux-en-Y Gastric Bypass by glucagon-like peptide-1 (GLP-1) receptor blockade.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Adrian Vella
Collaborators:
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Treatments:
Gastric Inhibitory Polypeptide
Hormones
Incretins
Criteria
Inclusion Criteria Roux-en-Y Gastric Bypass (RYGB)Subjects:

- Subjects who have undergone RYGB

Inclusion Criteria Healthy Subjects:

- Must match RYGB subjects in age, weight, and gender

- Subjects will be without active systemic illness

Exclusion Criteria all Subjects:

- Subjects <20 years old and >70 years old

- For Female Subjects: positive pregnancy text at the time of enrollment or study

- Subjects with functional or organic bowel symptoms.