The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate which method of naltrexone induction during rapid opioid detoxification causes stronger stress response and has a higher influence on opioid abstinence caused by opioid induction.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vilnius University
• Treatments: Analgesics, Opioid; Clonidine; Lorazepam; Naltrexone; Narcotic Antagonists

Criteria

Inclusion Criteria:

• Opiate addiction

• Use of short-acting opiate (morphine or heroine)

• Age > 18 years

• Length of opiate addiction > 1 year

• Patient can make a decision for detoxification and has a capacity to consent for procedure

• Written consent for procedure

Exclusion Criteria:

• Polyvalent addiction

• Pregnancy or breast feeding

• Cardiovascular pathology

• Acute or chronic kidney disease

• Decompensated liver pathology (jaundice, ascites, hepatic encephalopathy)

• Infective complications of opiate addiction (pneumonia, phlegmon, abscess, thombophlebitis, sepsis)

• Malnutrition (Nutritional risk screening 2002 score ≥3)

• Diabetes mellitus

• Previous history of psychosis

• Glasgow coma scale < 15

• Abdominal surgical intervention during last 30 days

• Cumulative buprenorphine dose for stabilization < 8 mg

• Positive test for psychoactive substances during treatment

• Refusal to participate in study at any point of it