The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid

• Status: Completed
• Trial end date: 2017-11-30
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare therapeutic and clinical effects of intra-articular injection of Bone Marrow Aspirate Concentrate (BMAC), inta-articular injection of Leukocyte Rich Platelet Rich plasma (LR-PRP) and 3 weekly doses of high molecular weight of Hyaluronic acid for the treatment of osteoarthritis (OA) of the knee ( KL scale II-IV).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Clinical Center of Vojvodina
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• history of complaints of knee pain because of the Knee Osteoarthritis with no relief using anti-inflammatory agents even after 3 months,

• Kellgren-Lawrence (KL) grade 2-4

• normal blood results and coagulation profile (platelets 150,000-450,000/l),

• patients who had not undergone any surgery on the affected knee within 2 years prior to the first injection and

• Mentally fit for clinical study

Exclusion Criteria:

• severe knee instability,

• severe misalignment,

• unicompartmental OA

• BMI more than 35

• inflammatory arthritis such as rheumatoid arthritis and ankylosing spondylitis

• presenting muscle pain underlying diseases such as hematologic disorders, septicemia, coagulopathy, neoplasm, active infection, and immune deficiency