The Combination Effect of Platelet-rich Plasma and Hyaluronic Acid for Knee Osteoarthritis

• Status: Completed
• Trial end date: 2021-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Although platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for osteoarthritis of knee (OA knee), the combined effect of PRP with HA was not clear so far. Hence, investigator assess a prospective randomized double-blind controlled trial.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tri-Service General Hospital
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

1. Age between 50 to 75 y/o.

2. Alert consciousness

3. Symptom of knee osteoarthritis persist at least 6 months and stage I to III scored by Ahlbäck grading system

4. The pain score measured by VAS at least 4 points

Exclusion Criteria:

1. Has received hyaluronic acid, PRP or steroid injection within 6 months

2. Has received NSAIDs or steroid within one week

3. Tumor or metastasis surrounding the knee joint

4. Has received total knee replacement, major surgery in knee, rheumatoid arthritis

5. Patient who cant tolerance the balance test.

6. Thrombocytopenia or coagulopathy