In this single center crossover study the aim is to investigate the effect of Ringer's
lactate solution at high and low temperatures on physiological response in healthy adults.18
healthy volunteers will be included. Inclusion criteria is; Age between 18-64. Exclusion
criteria is; Pre-existing medical problems, Pregnancy (validated through a certified
pregnancy test), Body mass index >35 kg/m2, Medication use apart from allergy medication,
contraceptives, or non-steroidal anti-inflammatory drugs.
Participants will be randomized to receive 30 ml/kg of Ringer's lactate either cold (15°C,
59°F), or at body temperature (37°C, 98.6°F) during a 30-minute interval. Fluids will be
administered through a peripheral vein. After a minimum "washout period" of 24 hours,
subjects are switched to receive infusion at the other aforementioned temperatures.
Primary outcome is
- The increase in MAP at 15 minutes after infusion of the fluid bolus. Secondary outcome
is
- Time until return of MAP to baseline value after infusion.
Phase:
Phase 4
Details
Lead Sponsor:
Hospital of South West Jutland
Collaborators:
Department of Clinical Biochemistry, Vejle Hospital Odense University Hospital Simon Fougner Hartmanns Family Foundation University of Southern Denmark