Overview

The Clinical Study of SHR-9839 for Injection in Patients With Advanced Solid Tumors

Status:
Not yet recruiting
Trial end date:
2026-06-01
Target enrollment:
0
Participant gender:
All
Summary
This study is an open-label, phase I clinical trial of SHR-9839 in patients with advanced solid tumors. The whole study is divided into three stages: dose escalation, dose expansion and efficacy expansion.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Shanghai Hengrui Pharmaceutical Co., Ltd.
Criteria
Inclusion Criteria:

1. Patients with histologically or cytologically confirmed unresectable locally advanced
or metastatic solid tumors which is relapsed or refractory to standard treatment, or
lack of standard treatment, or standard treatment is not applicable currently;

2. Have at least one measurable tumor lesion per RECIST v1.1;

3. ECOG performance status of 0-1;

4. Life expectancy ≥ 12 weeks;

5. Adequate bone marrow and organ function;

6. Subjects must voluntarily agree to participate in the trial and sign a written
informed consent form.

Exclusion Criteria:

1. Patients with active central nervous system metastases or meningeal metastases;

2. Received anti-tumor treatment such as chemotherapy, biotherapy, targeted therapy,
immunotherapy, radical radiotherapy, or other unlisted clinical research drugs or
treatments within 4 weeks prior to the first use of the study drug;

3. History of serious cardiovascular and cerebrovascular diseases;

4. Subjects who received>30Gy of radiation therapy within 4 weeks before the first
medication, and those who received ≤ 30Gy of palliative radiation therapy within 7
days before the first medication;

5. Adverse reactions of previous anti-tumor treatment have not recovered to Grade ≤ 1 per
NCI-CTCAE v5.0.