Overview

The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease

Status:
Completed

Trial end date:
2008-12-01

Target enrollment:
0

Participant gender:
All

Summary

This study attempts to differentiate the clinical responses of Choline Acetyltransferase and Apolipoprotein Epsilon gene polymorphism to donepezil in Alzheimer's Disease patients.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Eisai Korea Inc.

Treatments:

Choline
Donepezil

Criteria

Inclusion criteria:

1. Age: 60 - 90 years old.

2. CDR: 0.5 - 2.0.

3. Patients who do not have severe depressive symptoms that affect cognition on
depression scale of CERAD-K(C), GDS-K: 19 and below.

4. Modified Hachinski Ischemic Score (Rosen, et. al., 1979): 3 and below.

5. NINCDS-ADRDA criteria: Probable AD.

Exclusion criteria:

1. Patients who have delusions and other conscious dysfunction.

2. Patients who have neurologic diseases such as Parkinson's disease, stroke, tumor,
normal pressure hydrocephalus, etc., on history and neurologic examination.

3. Patients who have history of infectious and inflammatory brain disease owing to virus,
fungus and syphilis.

4. Patients with severe cerebrovascular pathology.

5. Patients who have present history of major psychological diseases such as depression
and mania according to DSM-IV criteria.

6. Patients who have history of alcoholism or drug addiction.

7. Patients who have severe depressive symptoms that affect cognition on depression scale
of CERAD-K.