Overview

The Chloroquine for Influenza Prevention Trial

Status:
Unknown status
Trial end date:
2010-08-01
Target enrollment:
0
Participant gender:
All
Summary
A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
National University Hospital, Singapore
Treatments:
Chloroquine
Chloroquine diphosphate
Criteria
Inclusion Criteria:

- Age 18 -65

- Have the ability to provide informed consent

- If a woman of child-bearing potential, willing to use contraception for the period of
the trial

Exclusion Criteria:

- Acute influenza-like illness at screening

- History of psoriasis, porphyria cutanea tarda, epilepsy, myasthenia gravis, myopathy
of any cause, cardiac arrhythmias, or serious hepatic or renal disease

- Pregnancy or breast feeding

- Current use of medication with known serious hepatotoxic effects

- Current use of medication with known serious interaction with CQ: amiodarone,
anticonvulsants, ciclosporin, digoxin, mefloquine, moxifloxacin

- Current severe depression (as indicated by current use of antidepressant medication)

- Known serious retinal disease

- Current or recent (within the past 30 days) participation in any other clinical
intervention trial.

- Known G6PD deficiency

- Vaccination for influenza (seasonal or H1N1 strain) within the 3 months prior to
screening