Pegylated interferon α-2a(Peg-IFN-α) not only inhibit viral replication, but also play an
important role in immune regulation, while Nucleoside analog(ue) drugs only inhibit viral
replication. In hepatitis B infection, cytokines played a vital role. This study was aimed at
investigating the changes of cytokines during Peg-IFN-αand nucleoside analog(ue)
therapy.Meanwhile, the investigators wanted to verify whether Peg-IFN-α therapy resulted in
the secretion of cytokines.