The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
Nitric oxide (NO) reflects changes in inflammatory state of the airways. In pulmonology
fractional exhaled nitric oxide concentration (FeNO) has been linked to eosinophilic asthma
and is used to guide overall disease control. The measurement of nasal nitric oxide (nNO) may
reflect the disease burden and inflammatory phenotype of the paranasal sinuses.
The aim of our study is to evaluate the relation of chronic rhino sinusitis (CRS) severity
and inflammatory status to nNO, maxillary sinus NO, nitrite, nitrate and cone beam computed
tomography (CBCT).
Three groups (22 patients in each) of referred patients and and 22 healthy volunteers are
recruited. Patients are grouped according to the CBCT score and viewed three times in 4-6
weeks intervals.