The Cardioprotective Effects of Adding Ozone To Cardioplegic Solution in Adult Cardiac Surgery
Status:
Not yet recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
forty patients with age ranged between 40-70 years undergoing elective coronary artery bypass
graft surgery with cardiopulmonary bypass will be included, they will divided into two
groups.
Ozone Group: in which Ozone will be added to cold blood cardioplegia. Control Group: in which
in which only cold blood cardioplegia
Primary outcome:
Pattern of recovery of myocardium after declamping of Aorta
1. Time of cardiac rhythm return after declamping.
2. type of cardiac rhythm after declamping and rate of DC use.
Secondary outcome:
A-cardiac parameters
- Post operative inotropic score
- Incidence of post operative cardiac dysrhythmias
- postoperative ejection fraction (EF)
- Postoperative parameters of myocardial ischaemia
- a- Troponin levels
- b-Pro BNP
- • Histopathology of myocardial sample for detection of myocyte cellular edema as a
marker of ischemic changes.
B-non cardiac parameters:
1. inflammatory markers 1. CRP 2. L\N 3. P\N
2. ICU stay
3. hospital stay
4. morbidity and mortality