Despite strict hand washing, sterile technique, and antibiotic-coated catheters, nosocomial
infection and sepsis remain the leading acquired causes of morbidity and mortality in
critically ill children. Subsequent use of antibiotics to treat nosocomial infection and
sepsis is considered a major attributable factor in the rise of antibiotic-resistant
organisms in this population of children. This study will use a double-blind, randomized,
controlled trial design to test the hypothesis that daily prophylaxis with metoclopramide,
zinc, selenium and glutamine will reduce nosocomial infection and sepsis in critically ill
children.
Phase:
Phase 3
Details
Lead Sponsor:
Michael Dean
Collaborators:
Arkansas Children's Hospital Research Institute Children's Hospital Los Angeles Children's Hospital of Michigan Children's National Research Institute Children's Research Institute Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Harborview Injury Prevention and Research Center Seattle Children's Hospital University of California, Los Angeles University of Pittsburgh