The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine
Status:
Terminated
Trial end date:
2017-05-01
Target enrollment:
Participant gender:
Summary
Investigators are comparing Ketamine to prochlorperazinecompazine for benign headaches in the
ED. Subjects will be randomized into 1 of 2 groups. Group 1 will receive standard treatment
of prochlorperazinecompazine 10 mg IV along with diphenhydramine 25 mg IV. Group 2 (research
arm) will receive Ketamine 0.3 mg/kg along with ondansetron 4 mg IV. Subjects will be seen at
15, 30, 45, and 60 minutes post-intervention to obtain Heart Rate, Blood Pressure, Headache
severity, Nausea severity, Vomiting severity, Anxiety severity, and Restlessness severity. At
24-48 hours post intervention we will contact subjects and assess their pain and assess their
satisfaction with their migraine pain management as part of this study. Subjects'
participation will last up to 48 hours post headache.
Phase:
Phase 3
Details
Lead Sponsor:
Mike O'Callaghan Federal Hospital Mike O'Callaghan Military Hospital