Overview

The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

Status:
Completed
Trial end date:
2017-03-21
Target enrollment:
0
Participant gender:
All
Summary
This study compares the efficacy of low dose Ketamine versus Compazine for the control of headache in patients presenting to the Emergency Department.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Medical Center of Southern Nevada
Treatments:
Diphenhydramine
Ketamine
Ondansetron
Prochlorperazine
Promethazine
Criteria
Inclusion Criteria:

- Age 18 to 65 years

- Temperature < 100.4° F

- Diastolic Blood Pressure <104 mm Hg

- Normal neurological exam and mormal mental status

Exclusion Criteria:

- Pregnant or breastfeeding.

- Meningeal signs are present

- Acute angle closure glaucoma is suspected.

- Head trauma within the previous two weeks

- Lumbar puncture within the previous two weeks

- Thunderclap onset of the headache

- Weight more than 150 kg or less than 40 kg.

- Known allergy to one of the study drugs.

- History of schizophrenia or bipolar disorder.

- History of intracranial hypertension.

- Is a prisoner

- Patient declined informed consent

- Non-English speaking patient.

- Attending provider excludes patient