The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
Dexmedetomidine is a sedative drug that has many benefits when given to children under
anesthesia, such as improved pain relief and reduced agitation following their surgery. It is
usually given as an intravenous infusion over 10 minutes, to avoid the changes in heart rate
and blood pressure that are occasionally seen when it is administered more quickly. However,
this is often infeasible and usually inconvenient. The investigators aim to determine the
dose of dexmedetomidine that can be given rapidly (over 5 seconds) without causing
significant changes in heart rate and blood pressure. This will be the only study specific
intervention.