The Best Dose of Esketamine for Day Surgery of Pediatric Circumcision Pediatric Circumcision
Status:
Recruiting
Trial end date:
2021-03-30
Target enrollment:
Participant gender:
Summary
In recent years, daytime operation has been developed gradually in China. Circumcision in
children is a common type of daytime operation. The nature of the operation and the object of
the operation determine that the anesthetic drugs used should induce fast, wake up quickly
and recover in a high quality.
Esketamine is an S-enantiomer of ketamine, which is newly marketed in China. Compared with
ketamine, it has stronger effect on NMDA receptor, and its sedative effect is about twice as
high. The occurrence frequency of respiratory depression and hypotension is lower than that
of other anesthetics and analgesics, which can provide good analgesic and sedative effect for
surgical anesthesia.
In clinical practice, ketamine combined with sevoflurane has been widely used in children's
microsurgery, but there has been no report on Esketamine combined with sevoflurane
anesthesia.
In order to find out the best combined dose, this paper compares the single administration of
three different doses of esketamine combined with sevoflurane anesthesia in the circumcision
of children.