The BEST Trial: Biomarkers for Evaluating Spine Treatments
Status:
Not yet recruiting
Trial end date:
2023-09-01
Target enrollment:
Participant gender:
Summary
The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a NIAMS-sponsored clinical
trial being conducted through the NIH HEAL Initiative's Back Pain Consortium (BACPAC)
Research Program. The primary objective of this trial is to inform a precision medicine
approach to the treatment of Chronic Low-Back Pain by estimating an algorithm for optimally
assigning treatments based on an individual's phenotypic markers and response to treatment.
Interventions being evaluated in this trial are: (1) enhanced self-care (ESC), (2) acceptance
and commitment therapy (ACT), (3) evidence-based exercise and manual therapy (EBEM), and (4)
duloxetine.
Phase:
Phase 4
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborator:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)