The Association Between Telomere Length and Propofol Dose in Anesthesia-induction
Status:
Unknown status
Trial end date:
2018-02-28
Target enrollment:
Participant gender:
Summary
Telomeres are protein-bound DNA repeat structures at the end of eukaryotic chromosomes that
are made up of a simple repetitive sequence (in humans, TTAGGG) and regulate cellular
replicative capacity and cellular proliferation, protect chromosomes from fusing together
during mitosis and maintain genomic stability, and prevent the loss of genetic data.
Telomeres are specialized repetitive DNA sequences, typically ranging from 5,000 to 15,000 bp
in humans, which are the critical chromosome capping DNA sequences. The loss of telomere
repeats diminishes telomeric functional capacity.Telomere length(TL) is important in
determining telomere function.This is known as the end replication problem and results in a
gradual decline in TL over time. Consequently,leukocyte TL shortens in a predictable way with
age by roughly 20-40 base pairs per year. Cellular senescence and subsequent cell death often
occur when the mean telomere length reaches a critical value.Shortened telomeres and lower
telomerase are linked to age-related risk factors and disease.Peripheral blood leukocyte
express telomerase at low levels, which can be measured over a short duration (hours) to
demonstrate immediate, short-term changes. Shorter mean leukocyte telomere length has been
shown to be associated with risk of several age-related diseases.The dosage of propofol
gradually reduced with the aging process. However,it is not known whether the telomere length
and variation of telomerase in PBL relate to the dosage of propofol and time of consciousness
disappearance in anesthesia induction. In this exploratory study, the investigators examined
that the changes of peripheral blood leukocyte telomere length was associated with the dosage
of propofol and time of consciousness disappearance in anesthesia induction.
Given the importance of telomeres in nuclear and cellular function, the central role of
telomere length in determining telomere function,the investigator study that the changes of
telomere length in peripheral blood leukocyte of patients are associated with the dosage of
propofol in anesthesia induction.
Phase:
N/A
Details
Lead Sponsor:
Guangzhou General Hospital of Guangzhou Military Command