The Association Between Peri-Operative Hyperglycemia and Major Morbidity and Mortality
Status:
Terminated
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
Surgery induces a stress effect on the body partially through a catabolic energy state. In
turn, glucose levels may rise to levels which have been associated with major morbidity
(Golden, 1999) and mortality (Ouattara, 2005). An increasing body of evidence suggests that
intensive insulin therapy for tight control of blood glucose levels in certain surgical and
critical care patient populations may improve mortality and selected morbidity outcomes when
compared to those patients receiving conventional insulin therapy and blood glucose
management. More specifically, poor intra-operative blood glucose control is associated with
worse outcome after cardiac surgery. Intensive insulin therapy with tight blood glucose
control in surgical patients while in the ICU may reduce morbidity and mortality. Such
outcome improvements would clearly provide benefits to patients, providers and payers. To
date, there is scant research examining whether intensive insulin therapy for tight control
of blood glucose in the perioperative period can alter outcomes for the non cardiac surgery
population. The purpose of this study is to determine whether intensive insulin therapy for
tight control of blood glucose in the perioperative period in non cardiac major surgery
patients is associated with altered morbidity and mortality rates.
Phase:
N/A
Details
Lead Sponsor:
University of Medicine and Dentistry of New Jersey