The Arterial Measurement of the Blood Flow Volume After Iloprost Stimulation

• Status: Unknown status
• Trial end date: 2019-06-01
• Target enrollment: 0
• Participant gender: All

Summary

A prospective case-control study was performed to investigate the effect of iloprost on the intraoperative flow volume in diabetic and non-diabetic patients as well as the effect of peripheral neuropathy in patients with peripheral arterial occlusive disease (PAOD) undergoing arterial reconstruction (primary endpoint).

100 patients undergoing femoral artery reconstruction or femorodistal bypass surgery were included. Prior to surgery, peripheral nerve conduction velocity was measured. Blood flow volume at the common femoral artery was assessed using a Doppler flowmeter (Sono TT FlowLab; ) before reconstruction, prior to the intraarterial application of 3000ng of iloprost and 5 and 10 minutes afterwards. Peripheral resistance units (PRU) were calculated as a function of mean systemic arterial pressure (MAP) and flow volume (VF): PRU = MAP (mmHg) / VF (ml/min).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Prim PD Dr Afshin Assadian
• Collaborator: Wilhelminenspital Vienna
• Treatments: Iloprost

Criteria

Inclusion Criteria:

• patients with diabetes and non diabetes

• patients with peripheral artery occlusive disease and who undergo surgical treatment in distal vessels

• spinal anesthesia

• written consent

Exclusion Criteria:

• pregnancy

• heart attack the last 6 months

• stroke the last 6 months

• hypotension

• edema of the lungs

• heart failure

• heart disease

• chronic obstructive pulmonary disease (COPD)

• ulcus ventriculi

• renal disease

• coronary disease

• immaturity

• general anesthesia