OBJECTIVE: To study the safety, efficacy and clinical significance of remimazolam in the
diagnosis and treatment of elderly obese patients with daytime gastrointestinal endoscopy,
calculate the optimal dose, and conduct relevant verification. Provide a safer and more
effective anesthesia solution for the growing special population.
METHODS：Around 160 patients were selected to receive painless gastroenteroscopy.，they were
divided into four groups of D1, D2, R and C. Group D1 and D2(including 60 patients) were used
to calculate the ED50 and ED95 of the drug. According to up-and-down method, they were slowly
injected 0.3μg/kg of remifentanil in advance, then 0.20mg/kg of remimazolam, and gastroscopy
was performed after MOAA/S score ≤３. The next patient would be increased 0.05mg/kg of
remimazolam if there is a positive standrd, otherwise it would be decreased 0.05mg/kg. And
the study was terminated when seven crossing points occurred. One hundred patients were
randomly divided into two groups of R and C.Before administration of remimazolam,
remifentanil injection 0.3 μg/kg were given intravenously in two groups, respectively
(injection rate was 30 s).Then group R was given the calculated dose of remimazolam, and
group C was given propofol 1.5-2mg/kg.The success rate of sedation, changes in vital signs,
adverse reactions, and postoperative recovery were recorded in the two groups.