The Anabolic Effect of Testosterone on Pelvic Floor Muscles
Status:
Not yet recruiting
Trial end date:
2026-07-01
Target enrollment:
Participant gender:
Summary
Stress urinary incontinence is the most common female pelvic floor disorder encountered in
clinical practice with significant negative impact on quality of life. The prevalence of
urinary incontinence increases with aging, and weakness of the pelvic floor muscles
contributes to the development of stress urinary incontinence. Given that androgen receptors
are expressed throughout the pelvic floor, the anabolic effects of androgens on pelvic floor
muscles may provide a therapeutic option in women with stress urinary incontinence. The
investigators are conducting a randomized, double-blind, placebo-controlled proof-of-concept
trial in older postmenopausal women with stress urinary incontinence to assess whether
testosterone therapy can increase pelvic floor muscles and improve urinary function.
Phase:
Phase 2
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)